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    Posted April 11, 2015 by
    KMFDallas
    Location
    Dallas, Texas
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    Diethylstilbestrol (DES) a step back in history….1940s

     

    Diethylstilbestrol (DES) was the first orally active estrogen available for clinical use and began to be prescribed in the 1940s. DES is not a steroid but rather a synthetic triphenylethelyene (Stilbene) derivative with estrogen receptor association kinetics and biologic activity equal to the most potent naturally-occurring estrogen, 17-beta-estradiol. At that time, a variety of clinical reproductive problems such as first trimester abortion, toxemia and gestational diabetes, were attributed to a deficiency of placental estrogen production. As a consequence of being readily available therapeutic estrogen, DES was given to pregnant women from the mid 1940s and into the 1970s in an attempt to alleviate these problems both therapeutically and prophylactically.

     

    It is now apparent that DES is a potent human reproductive tract teratogen in both sexes. Anomalies associated with prenatal DES in women include the following:
    • The presence of columnar epithelium in the vagina – adenosis
    • Structural cervical deformities – cock’s comb. Hood, collar and pseudopolyp
    • An altered uterine configuration with an irregular “T-shaped” endometrial cavity and an overall hypoplastic appearance
    • Missing segments of the fallopian tubes
    • Increased number of paraovarian cysts near the fimbrial ostia along with some unusual histology
    • DES also appears to affect mesonephric remnants in women (paraovarian cysts)

     

    These genital tract abnormalities have been associated with a variety of reproductive problems in women including infertility, spontaneous abortion, ectopic pregnancy and premature labor.

     

    Male offspring have also been noted to have anomalies associated with prenatal DES exposure, including abnormalities of the vas deferens, epidymus, urethra and the penile shaft. These organs derived from the mesonephric (Wolffian) ducts. A modest decrease in sperm counts have been observed.  DES Sons effects also include:

    Hypospadias, ambiguous genitalia, micro-penis and gender dysphoria. Gender dysphoria is reported in 150 out of 500 genetic males according to surveys conducted by Dr Scott Kerlin

     

    As The DES Tragedy continues to evolve, clinical problems are now being seen in the DES grandchildren. More research is needed.

     

    Any DES exposed individual is encouraged to tell their healthcare provided that they are DES Exposed and should write it on any screening form. Remember to bring DES related information to share and to educate your healthcare provider.

     

    The victims of The DES Tragedy are still awaiting an apology…… this story is not yet over

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